A city spokesperson said about 50 people were on the bus, several of them were injured.
A charter bus with around 50 passengers was struck by a freight train near Biloxi, Mississippi and at least 3 people have been confirmed dead.
Witnesses said the bus appeared stuck on the tracks and the eastbound train hit the bus broadside.
A Biloxi police official is calling it a "terrible, chaotic scene", according to NBC News.
The bus was believed to be full of senior citizens traveling to a local casino, WLOX reported. It is unclear why the bus was stopped on the tracks.
The Associated Press says the crash happened just before 2:15pm CT and pushed the bus about 300 feet down the tracks.
Emergency crews were seen removing passengers through emergency window exits on the bus.
The tour bus had been travelling from Austin in Texas when it crashed shortly after 2pm (8pm United Kingdom time), and it is thought those on board may have been heading to one of Biloxi's eight casinos.
"I took off running", Craig Robinson told the Sun Herald, describing the moment he saw the train headed toward the immobilized bus.